Mrs. Quagmire is the wife to Mr. Quagmire and mother to her triplets; Duncan, Isadora, and Quigley. Her first and maiden name is unknown. During the Quagmire fire, she sent Quigley down the secret passageway of the Quagmire Mansion in order to save his life before perishing herself along with her husband. Mrs. Quagmire was most likely a member of V.F.D. along it is never confirmed. She was one of two owners of the Quagmire Sapphires, the other person being Mr. Quagmire.
She is portrayed by Cobie Smulders in the TV series.